Genetic Arguments for the Prevention of Severe Forms of COVID-19 through Moderate-Intensity Exercise

Many severe forms of COVID-19 have genetic causes, with variants providing information and thus supporting the hypothesis that moderate-intensity exercise would a prophylactic role. In case abnormalities related to induction amplification type I interferons, in addition curative administration interferon, moderate intensity could be used prophylactically. The same exercises inhibit p38 MAPK pathway, being evaluated by clinical trials drug inhibition pathway. high physically active subjects, intermediate CCR2 monocyte decreased response exercise, Cenicriviroc, an antagonist chemokine CCR5/CCR2b receptor, has been proposed for therapy. Exercise prevents increased expression Tyk2, therapy, corresponding defect this gene, kinase inhibitors or Baricitinib proposed. critical analysis data presented paper shows prophylaxis COVID-19, used.